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Hydroxyurea

Hydroxyurea

Formedium

£969.38

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DNA replication inhibitor causing deoxyribonucleotide depletion CH4N2O2=76.05 Hydroxyurea is an anti-neoplastic which inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. Specifications Appearance White Crystalline Powder Content by HPLC 97.5 Water 0.5% Related substances 0.2% Residue on ignition 0.1% Heavy metals 10ppm Residue on ignition 0.1% Store at 2 - 8°C in dark, dry place

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